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SH7s

CAT: 0804-HY-159982Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159982Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SH7s is a potent carbonic anhydrases inhibitor, with Kis of 15.9 and 55.2 nM for hCA IX and hCA XII, respectively. SH7s is also a hypoxia-mediated chemo-sensitizing agent in colorectal cancer cells[1].
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sh7s.html
Smiles
O=S(C1=CC=C(N2N=CC(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)=C2C4=CC=C(OC)C=C4)C=C1)(N)=O
Molecular Formula
C24H19ClF3N5O4S
Molecular Weight
565.95
References & Citations
[1]Eldehna WM, et, al. 4- (Pyrazolyl) benzenesulfonamide Ureas as Carbonic Anhydrases Inhibitors and Hypoxia-Mediated Chemo-Sensitizing Agents in Colorectal Cancer Cells. J Med Chem. 2024 Nov 28;67 (22) :20438-20454.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19242013-01SH7s

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