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MICA Antibody

CAT: 0800-V9703-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9703-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MICA and MICB are stress-induced antigens that are related to major histocompatibility complex (MHC) class I molecules. MICA and MICB are frequently expressed in epithelial tumors. These highly glycosylated cell surface proteins are stably expressed without conventional class I peptide ligands or association with -2-microglobulin. The expression is induced on proliferating or heat shock-stressed epithelial cells. MICA and MICB are broadly recognized by intestinal epithelial γδ T cells expressing variable TCRs, suggesting that these antigens may play a central role in the signaling of cellular distress to evoke immune responses in the intestinal epithelium.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q29983
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 1-200 was used as the immunogen for the MICA antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
MICA/4443
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the MICA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MICA antibody is available for research use only.
Storage Conditions
Aliquot the MICA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the MICA antibody should be determined by the researcher.
Location
Cell surface, Cytoplasm
Image Legend
IHC staining of FFPE human stomach with MICA antibody (clone MICA/4443) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q29983

MHC class I polypeptide-related sequence A

MICA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q29983
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MICA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MIC-A
EC number
—
Processing
Precursor
Secondary accessions
A8KQR0, A9LRW5, A9QVE0, B1VJF1, O60917, O60918, O60919, O60920, O60933, O77956, O78150, O78151, O78152, O78153, O97987, O97988, O97989, O97990, O97991, O97992, O97993, O97994, O97995, O98234, O98235, O98236, O98237, O98238, P79506, P79507, P79508, P79509, P79510, P79511, P79512, P79513, P79514, P79515, P79516, P79517, P79518, P79519, P79520, P79521, Q5C9P8, Q5XM81, Q70I48, Q70I49, Q7JFH9, Q7JFI0, Q7JFI1, Q7JFI2, Q7YQ98, Q861I1, Q95464, Q95HA2, Q95HD6, Q95HN4, Q95HN5, Q95HN6, Q95IB2, Q95IY7, Q99692, Q9BCR3, Q9BCR4, Q9BCR5, Q9BCR6, Q9BCR7, Q9BCR8, Q9BCR9, Q9BCS0, Q9BCS1, Q9BCS2, Q9BCS3, Q9BCS4, Q9BD20, Q9GIZ1, Q9GIZ2, Q9GIZ3, Q9GIZ4, Q9GIZ5, Q9GIZ6, Q9GJ01, Q9GJ02, Q9GJ03, Q9GJ04, Q9GJ05, Q9GJ06, Q9GJ07, Q9GJ08, Q9GJ09, Q9MY21, Q9TQ86, Q9TQ87, Q9TQ88, Q9TQ89, Q9TQ92, Q9TQ93, Q9TQ94, Q9TQ95, Q9TQ96, Q9TQ97, Q9TQ98, Q9TQ99, Q9TQA0, Q9TQA1, Q9TQA2, Q9TQA3, Q9TQA4, Q9TQI9, Q9TQJ0, Q9TQJ1, Q9TQJ9, Q9TQK0, Q9TQK1, Q9TQK2, Q9TQK8, Q9TQK9, Q9TQL0, Q9TQL1, Q9TQL2, Q9TQL3, Q9TQL4, Q9UE04, Q9UE05, Q9UE06, Q9UE11
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityCytolysisHost-virus interactionImmunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmMembrane

PTM

Disulfide bondGlycoproteinLipoproteinPalmitateUbl conjugation

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

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