MEF2B Antibody

CAT: 0800-V9641-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V9641-20UGSize:20 µg
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Description
The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four family members, termed MEF-2A, -2B, -2C, and -2D, arise from alternatively spliced transcripts. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5, and MRF4, are one class of identified factors. The MEF-2 family represents a second class of DNA binding regulatory proteins. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL
UniProt
Q02080
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human MEF2B protein was used as the immunogen for the MEF2B antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
PCRP-MEF2B-2F9
Applications
WB, FACS, IF
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the MEF2B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MEF2B antibody is available for research use only.
Storage Conditions
Aliquot the MEF2B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the MEF2B antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Immunofluorescent staining of PFA-fixed human HeLa cells using MEF2B antibody (green, clone PCRP-MEF2B-2F9) and phalloidin (red) .

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