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Tyrosinase Antibody

CAT: 0800-V9597-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9597-100UGSize:100 µg
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Description
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants.This MAb is a useful marker for melanocytes and melanomas.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P14679
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human Tyrosinase protein was used as the immunogen for the Tyrosinase antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
TYR/3826
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Tyrosinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Tyrosinase antibody is available for research use only.
Storage Conditions
Aliquot the Tyrosinase antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Tyrosinase antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
IHC staining of FFPE human skin with Tyrosinase antibody (clone TYR/3826) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P14679

Tyrosinase

TYRO_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P14679
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TYR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.18.1
Processing
Precursor
Secondary accessions
Q15675, Q15676, Q15680, Q8TAK4, Q9BYY0, Q9BZX1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Disease

AlbinismDeafnessDisease variantWaardenburg syndrome

Coding sequence diversity

Alternative splicing

Ligand

CopperMetal-binding

PTM

Glycoprotein

Biological process

Melanin biosynthesis

Cellular component

Membrane

Molecular function

MonooxygenaseOxidoreductaseTumor antigen

Domain

SignalTransmembraneTransmembrane helix

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