IL3 Antibody

CAT: 0800-V9546-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V9546-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P08700
Host
Mouse
Reactivity
Human
Immunogen
A recombinant protein fragment was used as the immunogen for the IL3 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
IL3/4001
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the IL3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IL3 antibody is available for research use only.
Storage Conditions
Aliquot the IL3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the IL3 antibody should be determined by the researcher.
Location
Secreted
Image Legend
IHC staining of FFPE human adrenal gland tissue with IL3 antibody (clone I L3/4001) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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