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Fetuin-A Antibody / AHSG

CAT: 0800-V9480-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V9480-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fetuin (also designated 2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P02765
Host
Mouse
Reactivity
Human
Immunogen
A recombinant protein fragment was used as the immunogen for the Fetuin-A antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
AHSG/3748
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Fetuin-A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Fetuin-A antibody is available for research use only.
Storage Conditions
Aliquot the Fetuin-A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Fetuin-A antibody should be determined by the researcher.
Location
Secreted
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using Fetuin-A antibody (clone AHSG/3748) . These results demonstrate the foremost specificity of the AHSG/3748 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
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