Recombinant CDH16 Antibody / Cadherin 16

• Description:

  This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin/cadherin 16/CDH16. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

• Specifications:

  Immunohistochemistry (FFPE) : 1-2 µg/mL

• UniProt:

  O75309

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant human full-length protein was used as the immunogen for the recombinant CDH16 antibody.

• Clonality:

  Recombinant Monoclonal

• Isotype:

  IgG

• Clone:

  CDH16/7028R

• Type:

  Recombinant

• Applications:

  IHC-P

• Purity:

  Protein A affinity

• Format:

  Purified

• Buffer:

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution:

  Aliquot the recombinant CDH16 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This recombinant CDH16 antibody is available for research use only.

• Storage Conditions:

  Aliquot the recombinant CDH16 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  1 mg/mL in 1X PBS; BSA free, sodium azide free

• Applications Notes:

  Optimal dilution of the recombinant CDH16 antibody should be determined by the researcher.

• CAS Number:

  9000-83-3

• Location:

  Cell Surface and Cytoplasmic

• Image Legend:

  IHC staining of FFPE human thyroid tissue with recombinant CDH16 antibody (clone CHD16/7027R) at 2ug/ml in PBS for 30min RT. Negative control inset: PBS used instead of primary antibody to control for secondary Ab binding. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.