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Recombinant CD30 Antibody

CAT: 0800-V9437SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9437SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. Its epitope is located somewhere between aa 580-595 (cytoplasmic) . CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45) .
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P28908
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 495-595 was used as the immunogen for the recombinant CD30 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RKi-1/6913
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the recombinant CD30 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant CD30 antibody is available for research use only.
Storage Conditions
Aliquot the recombinant CD30 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant CD30 antibody should be determined by the researcher.
Location
Cell Surface
Image Legend
IHC staining of FFPE human Hodgkins lymphoma tissue with recombinant CD30 antibody (clone rKi-1/6913) at 2ug/ml in PBS for 30min RT. Staining of Reed-Sternberg cells is observed. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P28908

Tumor necrosis factor receptor superfamily member 8

TNR8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P28908
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFRSF8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B1AN79, B9EGD9, D3YTD8, Q6P4D9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative initiationAlternative splicing

Cellular component

Cell membraneCytoplasmMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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