Beta-2 Microglobulin Recombinant Antibody

Beta-2 Microglobulin Recombinant Antibody

• Description: Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
• CAS Number: 9000-83-3
• UniProt: P61769
• Host: Mouse
• Immunogen: Recombinant full-length human B2M protein was used as the immunogen for the recombinant Beta-2 Microglobulin antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Type: Recombinant
• Applications: IHC-P
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Aliquot the recombinant Beta-2 Microglobulin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This recombinant Beta-2 Microglobulin antibody is available for research use only.