Thyroid Stimulating Hormone Receptor / TSHR Recombinant Antibody (beta chain)

• Description:

  Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Grave s disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

• UniProt:

  P16473

• Host:

  Rabbit

• Immunogen:

  Recombinant human TSHR B-Chain protein was used as the immunogen for the recombinant TSH Receptor antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG κ

• Type:

  Recombinant

• Applications:

  IHC-P

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

• Reconstitution:

  Aliquot the recombinant TSH Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This recombinant TSH Receptor antibody is available for research use only.

• CAS Number:

  9000-83-3