Hexamethonium (Bromide)

CAT: 0804-HY-B0569-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0569-01Size:500 mg
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Description
Hexamethonium Bromide is a non-selective ganglionic nicotinic-receptor antagonist (nAChR) antagonist, with mixed competitive and noncompetitive activity. Hexamethonium Bromide has anti-hypertensive activity. Hexamethonium Bromide attenuates sympathetic activity and blood pressure in spontaneously hypertensive animal models[1][2][3][4].
CAS Number
[55-97-0]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; nAChR
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hexamethonium-bromide.html
Purity
99.91
Solubility
DMSO : 16.67 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
Molecular Formula
C12H30Br2N2
Molecular Weight
362.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Damian J. Williams, et al. Mechanisms involved in nicotinic acetylcholine receptor-induced neurotransmitter release from sympathetic nerve terminals in the mouse vas deferens. PLoS One. 2011; 6 (12) : e29209.|[2]Roger L. Papke, et al. Activation and Inhibition of Mouse Muscle and Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes. J Pharmacol Exp Ther. 2010 May; 333 (2) : 501–518.|[3]Brian T Hawkins, et al. Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors. Am J Physiol Heart Circ Physiol. 2005 Jul;289 (1) :H212-9.|[4]Peng Li, et al. Hexamethonium attenuates sympathetic activity and blood pressure in spontaneously hypertensive rats. Mol Med Rep. 2015 Nov;12 (5) :7116-22.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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