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AZ14133346

CAT: 0804-HY-163663Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163663Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ14133346 (compound 36) is a potent and selective inhibitor of EGFR Exon20 insertions, with the IC50 of 85 nM. AZ14133346 plays an important role in cancer research[1].
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/az14133346.html
Smiles
C=CC(N1C[C@@H](N2N=C(C3=CC=CC(/C=C/C4=NC=C(C5CC5)O4)=C3)C(C6=CC=NC=C6)=C2)CC1)=O
Molecular Formula
C29H27N5O2
Molecular Weight
477.56
References & Citations
[1]Clare Thomson, et al. Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J Med Chem. 2024 Jun 13;67 (11) :8988-9027.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19262615-01AZ14133346

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