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Toripalimab Biosimilar - Research Grade

CAT: 1148-ICH5002-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:1148-ICH5002-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Pembrolizumab biosimilar is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. It is an IgG4 kappa immunoglobulin with an approximate molecular weight of 149 kDa.
Specifications
Detects human PD-1. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Toripalimab.
Product Name Alternative
Programmed cell death protein 1, Pdcd1, CD279
UniProt
Q15116
Host
Humanized
Species Reactivity
Human
Target
PD-1
Isotype
IgG4
Applications
Functional Assays
Purification Method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Concentration
1.0 - 5.0 mg/mL
Endotoxin
<1EU/mg Determined by LAL gel clotting assay
Purity
>95% by SDS-PAGE and HPLC
Buffer
ICH3002
Shipping Conditions
Blue ice
Storage Conditions
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation
Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.
Applications Notes
This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Isotype Control
https://ichor.bio/product/bulk-human-igg4-isotype-control-ib4-ich2257/

UniProtKB · Q15116

Programmed cell death protein 1

PDCD1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15116
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDCD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Protein PD-1, hPD-1
EC number
—
Processing
Precursor
Secondary accessions
O00517, Q8IX89
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityApoptosisImmunity

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

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