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Evolocumab Biosimilar - Research Grade

CAT: 1148-ICH4023-20mgSize: 20 mgDry Ice: NoHazardous: No
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CAT#:1148-ICH4023-20mgSize:20 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Evolocumab biosimilar is a human monoclonal immunoglobulin G2 (IgG2) directed against human proprotein convertase subtilisin kexin 9 (PCSK9). Evolocumab biosimilarhas an approximate molecular weight (MW) of 144 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells.
Specifications
Detects human PCSK9. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Evolocumab.
Product Name Alternative
Proprotein convertase subtilisin/kexin type 9, NARC-1, PC9
UniProt
Q8NBP7
Host
Humanized
Species Reactivity
Human
Target
PCSK9
Isotype
IgG2
Purification Method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Concentration
1.0 - 5.0 mg/mL
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE and HPLC
Buffer
ICH3001-100mL ICH3002-100mL ICH3003-100mL
Shipping Conditions
Blue ice
Storage Conditions
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation
Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.
Isotype Control
https://ichor.bio/product/bulk-human-igg2-isotype-control-ib2-ich2255/

UniProtKB · Q8NBP7

Proprotein convertase subtilisin/kexin type 9

PCSK9_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NBP7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PCSK9
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.-
Processing
Precursor
Secondary accessions
A8T640, C0JYY9, Q5PSM5, Q5SZQ2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCholesterol metabolismLipid metabolismSteroid metabolismSterol metabolism

PTM

Autocatalytic cleavageDisulfide bondGlycoproteinPhosphoproteinSulfationZymogen

Ligand

Calcium

Cellular component

CytoplasmEndoplasmic reticulumEndosomeGolgi apparatusLysosomeSecreted

Disease

Disease variant

Molecular function

HydrolaseProteaseSerine protease

Domain

Signal

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