Bulk Anti-Human EGFR (EGFR.1) Antibody - Ultra-Low Endotoxin

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

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CAT:

1148-ICH1021UL-25mg

Size:

25 mg

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Bulk Anti-Human EGFR (EGFR.1) Antibody - Ultra-Low Endotoxin

Background: The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor A (TGFA) (note, a full list of the ligands able to activate EGFR and other members of the ErbB family is given in the ErbB article). ErbB2 has no known direct activating ligand, and may be in an activated state constitutively or become active upon heterodimerization with other family members such as EGFR. Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer - although there is some evidence that preformed inactive dimers may also exist before ligand binding. In addition to forming homodimers after ligand binding, EGFR may pair with another member of the ErbB receptor family, such as ErbB2/Her2/neu, to create an activated heterodimer. There is also evidence to suggest that clusters of activated EGFRs form, although it remains unclear whether this clustering is important for activation itself or occurs subsequent to activation of individual dimers.
Specifications: Anti-EGFR In Vivo Antibody - Ultra Low Endotoxin (EGFR.1) recognizes an epitope on Human EGFR
Alternative Name: Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, ERBB, ERBB1, HER1
UniProt: P00533
Host: Mouse
Species Reactivity: Human
Target: EGFR
Isotype: IgG2b Kappa
Clone: EGFR.1
Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, IHC (Frozen), Immunoprecipitation, Neutralization, IP-Mass Spectrometry
Purification Method: This monoclonal antibody was purified using Protein A
Concentration: 1.0 - 5.0 mg/mL
Endotoxin: ≤ 0.5 EU/mg as determined by the LAL method
Purity: >98% by SDS-PAGE and HPLC
Buffer: ICH3001-100mL ICH3002-100mL ICH3003-100mL
Shipping Conditions: Blue ice
Storage Conditions: Anti-EGFR In Vivo Antibody - Ultra Low Endotoxin (EGFR.1) is stable when stored at 2-8°C. Do not freeze.
Formulation: 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Aggregation: Aggregation level ≤ 1%
Applications Notes: Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control: https://www.ichor.bio/product/Mouse-IgG2b-Isotype-Control-for-In-Vivo-Low-Endotoxin-MPC-11-ICH2250

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Cat	Name
ICH1021-100mg	Bulk Anti-Human EGFR (EGFR.1) Antibody
ICH1021-50mg	Bulk Anti-Human EGFR (EGFR.1) Antibody
ICH1021-25mg	Bulk Anti-Human EGFR (EGFR.1) Antibody
ICH1021-5mg	Bulk Anti-Human EGFR (EGFR.1) Antibody
ICH1021UL-100mg	Bulk Anti-Human EGFR (EGFR.1) Antibody - Ultra-Low Endotoxin
ICH1021UL-50mg	Bulk Anti-Human EGFR (EGFR.1) Antibody - Ultra-Low Endotoxin
ICH1021UL-25mg	Bulk Anti-Human EGFR (EGFR.1) Antibody - Ultra-Low Endotoxin
ICH1021UL-5mg	Bulk Anti-Human EGFR (EGFR.1) Antibody - Ultra-Low Endotoxin
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