Itameline

• Description :

  Itameline (RU 47213) is a prodrug with oral and long-lasting cholinergic activity. Itameline is a novel tetrahydropyridine-oxime that is cleaved in vivo to form an active metabolite, RU 35963. RU 35963 is a muscarinic receptor agonist that is nonselective with respect to receptor subtypes. Itameline possesses the capacity to reduce memory deficits induced by an impairment of cholinergic transmission in the rat[1].

• Product Name Alternative :

  RU 47213

• UNSPSC :

  12352005

• Target :

  Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/itameline.html

• Smiles :

  O=C(N1CCC=C(/C=N/OC)C1)OC2=CC=C(Cl)C=C2

• Molecular Formula :

  C14H15ClN2O3

• Molecular Weight :

  294.73

• References & Citations :

  [1]M M'Harzi, et al. Ameliorating effects of RU 47213, a novel oral and long-lasting cholinomimetic agent, on working memory impairments in rats. Pharmacol Biochem Behav. 1997 Apr;56 (4) :663-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [145071-44-9]