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Lisuride

CAT: 0804-HY-12713-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12713-05Size:50 mg
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Description
Lisuride is an orally active dopamine D2 receptors agonist. Lisuride, as an ergot derivative, can be used for the research of Parkinson's disease, migraine, and high prolactin levels[1][2].
CAS Number
18016-80-3
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lisuride.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1[C@@]2([H])C(C3=CC=CC4=C3C(C2)=CN4)=C[C@@H](C1)NC(N(CC)CC)=O
Molecular Formula
C20H26N4O
Molecular Weight
338.45
Precautions
H315, H319, H320
References & Citations
[1]Rinne UK. Lisuride, a dopamine agonist in the treatment of early Parkinson's disease. Neurology. 1989;39 (3) :336-339.|[2]Kehr W. Effect of lisuride and other ergot derivatives on monoaminergic mechanisms in rat brain. Eur J Pharmacol. 1977;41 (3) :261-273.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D2 Receptor

Chemical Information

Lisuride

Lisuride is a monocarboxylic acid amide. It has a role as a serotonergic agonist, an antiparkinson drug, a dopamine agonist and an antidyskinesia agent. It derives from a hydride of an ergoline.

CAS Number18016-80-3
PubChem CID28864
IUPAC Name3-[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea
Molecular FormulaC20H26N4O
Molecular Weight338.4
XLogP2.7
Topological Polar Surface Area51.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity544
SMILES
CCN(CC)C(=O)N[C@@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C
InChI
InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1
InChIKey
BKRGVLQUQGGVSM-KBXCAEBGSA-N
Chemical Structure
2D Structure
2D structure of Lisuride
CAS: 18016-80-3
CID: 28864
Formula: C20H26N4O
MW: 338.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight338.4
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass338.21066147
Monoisotopic Mass338.21066147
Topological Polar Surface Area51.4 Ų
Heavy Atom Count25
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T61065-01Lisuride
FL24912-01Lisuride maleate
281260-01Lisuride discontinued
TRC-D449495-1MGtrans-Dihydro Lisuride
TRC-D449497-1MGtrans-Dihydro Lisuride-d10
453794-01Lisuride Maleate discontinued. See 255690

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