Detomidine

• Description:

  Detomidine, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine produces dose-dependent analgesic effects[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H320

• Target:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Neurological Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/detomidine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(C)C(CC2=CN=CN2)=CC=C1

• Molecular Formula:

  C12H14N2

• Molecular Weight:

  186.25

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8 (1) :30-7.|[2]J Still, et al. Cardiovascular and respiratory effects of detomidine in isoflurane-anaesthetised horses. J S Afr Vet Assoc. 1996 Dec;67 (4) :199-203.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  α adrenergic receptor

• CAS Number:

  [76631-46-4]