WFS1 Antibody / Wolframin

WFS1 Antibody / Wolframin

• Description: Wolframin is a protein that in humans is encoded by the WFS1 gene. This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene.
• CAS Number: 9007-83-4
• UniProt: O76024
• Host: Rabbit
• Immunogen: E. coli-derived recombinant human protein (amino acids D272-K876) was used as the immunogen for the WFS1 antibody.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB, Direct ELISA
• Format: Antigen affinity purified
• Buffer: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Reconstitution: After reconstitution, the WFS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
• Limitations: This WFS1 antibody is available for research use only.