Tocainide

• Description:

  Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/tocainide.html

• Concentration:

  10mM

• Purity:

  99.72

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  CC(N)C(NC1=C(C)C=CC=C1C)=O

• Molecular Formula:

  C11H16N2O

• Molecular Weight:

  192.26

• Precautions:

  H302

• References & Citations:

  [1]Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3 (6) :316-23.|[2]De Luca A, et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64 (4) :932-45.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [41708-72-9]