Klotho Antibody

• Description:

  May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity) . Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity) . [UniProt]

• Specifications:

  Western blot: 1:2000

• UniProt:

  Q9UEF7

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  Recombinant human Klotho was used as the immunogen for the Klotho antibody.

• Clonality:

  Polyclonal

• Isotype:

  Ig

• Applications:

  WB

• Purity:

  Antigen affinity

• Format:

  Antigen affinity purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the Klotho antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This Klotho antibody is available for research use only.

• Storage Conditions:

  Aliquot the Klotho antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  The stated application concentrations are suggested starting points. Titration of the Klotho antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• Prediction Reactivity:

  Human

• CAS Number:

  9007-83-4

• Image Legend:

  Western blot testing of Kloto antibody at 1:2000 + mouse brain lysate. Predicted molecular weight ~116 kDa, observed at 120-135 kDa.