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HACE1 Antibody

CAT: 0800-F54120-0.05MLSize: 0.05 mLDry Ice: NoHazardous: No
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CAT#:0800-F54120-0.05MLSize:0.05 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 is an E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:2000
UniProt
Q8IYU2
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human HACE1 was used as the immunogen for the HACE1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1854CT757.66.47
Applications
WB
Purity
Protein G purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the HACE1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HACE1 antibody is available for research use only.
Storage Conditions
Aliquot the HACE1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the HACE1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of HACE1 antibody at 1:2000: Lane 1) human HEK293 and 2) 293T/17 cell lysate. Predicted molecular weight ~102 kDa.

UniProtKB · Q8IYU2

E3 ubiquitin-protein ligase HACE1

HACE1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IYU2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HACE1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.26
Processing
—
Secondary accessions
A8K6U5, B3KY89, B4DFM6, B4DTQ4, B7Z9X6, E9PGP0, Q5VU99, Q5VUA0, Q8ND12, Q9P2M6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Domain

ANK repeatRepeat

Biological process

Cell cycleTranscriptionTranscription regulationUbl conjugation pathway

Cellular component

CytoplasmEndoplasmic reticulumGolgi apparatusMembrane

Disease

Disease variantHereditary spastic paraplegiaNeurodegeneration

Molecular function

Transferase

PTM

Ubl conjugation

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