Chicanine

• Description :

  Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity[1].

• UNSPSC :

  12352005

• Target :

  ERK; IKK; p38 MAPK

• Type :

  Natural Products

• Related Pathways :

  MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/chicanine.html

• Purity :

  99.96

• Solubility :

  DMSO : 18 mg/mL (ultrasonic; warming)

• Smiles :

  OC1=CC=C([C@@H]2O[C@@H](C3=CC=C(OCO4)C4=C3)[C@H](C)[C@@H]2C)C=C1OC

• Molecular Formula :

  C20H22O5

• Molecular Weight :

  342.39

• References & Citations :

  [1]Chicanine, et al. Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways. Eur J Pharmacol. 2014 Feb 5;724:168-74.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [78919-28-5]