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SACS Polyclonal Antibody

CAT: 0965-JOT-AP14028-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP14028-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al., PubMed: 19208651).
CAS Number
9007-83-4
Synonyms
Sacsin ;DnaJ homolog subfamily C member 29;DNAJC29
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 4291-4340
Clonality
Polyclonal
Applications
IHC-p, IF
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG

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