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OAZ3 Polyclonal Antibody

CAT: 0965-JOT-AP12164-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP12164-01Size:20 µL
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Background
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that ho
CAS Number
9007-83-4
Synonyms
Ornithine decarboxylase antizyme 3 ;AZ3;ODC-Az 3
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG

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