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KBRS2 Polyclonal Antibody

CAT: 0965-JOT-AP10621-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP10621-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.,Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.,sequence Absence of residues from position 133 within an exon that change the frame which is not the result of an alternative splicing.,Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.,subunit:Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo.,tissue specificity:Widely expressed.,
CAS Number
9007-83-4
Synonyms
NF-kappa-B inhibitor-interacting Ras-like protein 2 ;I-kappa-B-interacting Ras-like protein 2;Kappa B-Ras protein 2;KappaB-Ras2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG

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