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GALR2 Polyclonal Antibody

CAT: 0965-JOT-AP09384-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP09384-01Size:20 µL
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Background
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simul
CAS Number
9007-83-4
Synonyms
Galanin receptor type 2 ;GAL2-R;GALR-2; GALR2; GALNR2; Galanin receptor type 2; GAL2-R; GALR-2
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic Peptide of GALR2
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG

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