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AR Polyclonal Antibody

CAT: 0965-JOT-AP14284-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP14284-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform
CAS Number
9007-83-4
Synonyms
Androgen receptor; AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human AR.
Clonality
Polyclonal
Applications
IF, ICC, WB, IHC-p, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
98989
Antibody Type
Primary antibody
Isotype
IgG

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