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WRN Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP05511-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP05511-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism| including transcription| replication| recombination| and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity| and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing| this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome| an autosomal recessive disorder characterized by premature aging.
CAS Number
9007-83-4
Synonyms
WRN; Werner syndrome ATP-dependent helicase; EC 3.6.4.12; DNA helicase; RecQ-like type 3; RecQ3; Exonuclease WRN; EC 3.1.-.-; RecQ protein-like 2
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from human WRN
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
157520
Antibody Type
Primary antibody
Isotype
IgG

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