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UBP20 Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP13344-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP13344-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex| this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis| glucose metabolism| cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein.
CAS Number
9007-83-4
Synonyms
UBP20
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human UBP20
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
100540
Antibody Type
Primary antibody
Isotype
IgG