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SIG12 Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP04747-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP04747-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains| and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein| upon tyrosine phosphorylation| has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Synonyms
SIG12
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human SIG12
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
65450
Antibody Type
Primary antibody
Isotype
IgG

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