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PSME1 Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP04321-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP04321-01Size:20 µL
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Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes| a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base| which contains 6 ATPase subunits and 2 non-ATPase subunits| and a lid| which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome| the immunoproteasome| is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator| referred to as the 11S regulator or PA28| that replaces the 19S regulator. Three subunits (alpha| beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator| one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Synonyms
PSME1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human PSME1
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
27390
Antibody Type
Primary antibody
Isotype
IgG

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