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(-​) ​-Maackiain

CAT: 0804-HY-N6051-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6051-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-) -Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-) -Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-) -Maackiain is orally active[1][2].
CAS Number
2035-15-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fungal; NF-κB; NOD-like Receptor (NLR)
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/maackiain.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C([C@@]2([H])[C@@](C3=C(C=C4C(OCO4)=C3)O2)([H])CO5)C5=C1
Molecular Formula
C16H12O5
Molecular Weight
284.27
Precautions
H302, H315, H319, H335
References & Citations
[1]ScottSoby, et al. Detoxification of the phytoalexins maackiain and medicarpin by fungal pathogens of alfalfa. Phytochemistry. 1996 Feb;14 (3) :759-765.|[2]Huh JW, et al., Maackiain, a compound derived from Sophora flavescens, increases IL-1β production by amplifying nigericin-mediated inflammasome activation. FEBS Open Bio. 2020 Aug;10 (8) :1482-1491.|[3]Mizuguchi H, et al., Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes. Pharmacol Res Perspect. 2015 Oct;3 (5) :e00166.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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