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MBD2 Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP03548-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP03548-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2| MBD1| MBD2| MBD3| and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins| with the exception of MBD3| is capable of binding specifically to methylated DNA. MECP2| MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription| as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Synonyms
MBD2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human MBD2
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
45210
Antibody Type
Primary antibody
Isotype
IgG

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