GPX4 Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the glutathione peroxidase family| members of which catalyze the reduction of hydrogen peroxide| organic hydroperoxides and lipid hydroperoxides| and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates| which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus| it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase| as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein| containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon| which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure| designated the Sec insertion sequence (SECIS) element| that is necessary for the recognition of UGA as a Sec codon| rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

9007-83-4

GPX4; Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHGPx; EC 1.11.1.12; Glutathione peroxidase 4; GPx-4; GSHPx-4

Human, Rat, Mouse

Synthesized peptide derived from human GPX4

WB

-20°C for 1 year

1 mg/ml

Primary antibody