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GALE Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP10117-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP10117-01Size:20 µL
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Background
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose| and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose| but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia| also referred to as galactosemia type 3| a disease characterized by liver damage| early-onset cataracts| deafness and mental retardation| with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
CAS Number
9007-83-4
Synonyms
GALE
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human GALE
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
38280
Antibody Type
Primary antibody
Isotype
IgG

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