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DQB1 Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP02305-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP02305-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB)| both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes| dendritic cells| macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide| exons 2 and 3 encode the two extracellular domains| exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities| resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro
CAS Number
9007-83-4
Synonyms
DQB1
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from human DQB1
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
28710
Antibody Type
Primary antibody
Isotype
IgG

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