Products for Research Use Only

DAB2 Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP08887-01Size: 20 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0965-JOT-AP08887-01Size:20 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells| but is down-regulated or absent from ovarian carcinoma cell lines| suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2| an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras)| via its C-terminal proline-rich sequences| and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Synonyms
DAB2; Disabled homolog 2; DOC-2; Differentially-expressed protein 2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human DAB2
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG