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PAK4(Phospho Ser474) Polyclonal Antibody

CAT: 0965-JOT-AP07484-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP07484-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PAK proteins| a family of serine/threonine p21-activating kinases| include PAK1| PAK2| PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
CAS Number
9007-83-4
Synonyms
Serine/threonine-protein kinase PAK 4; PAK4; KIAA1142; Serine/threonine-protein kinase PAK 4; p21-activated kinase 4; PAK-4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PAK4/5/6 around the phosphorylation site of Ser474. AA range:441-490
Clonality
Polyclonal
Applications
WB, IHC-p, IF, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
64072
Antibody Type
Primary antibody
Isotype
IgG

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