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MDM2(Phospho Ser166) Polyclonal Antibody

CAT: 0965-JOT-AP06974-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP06974-01Size:20 µL
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Background
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins| such as p53| for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants| many of which may be expressed only in tumor cells.
CAS Number
9007-83-4
Synonyms
E3 ubiquitin-protein ligase Mdm2; MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2
Host
Rabbit
Reactivity
Human, Mouse, Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human MDM2 around the phosphorylation site of Ser166. AA range:132-181
Clonality
Polyclonal
Applications
WB, IHC-p, IF, ICC, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
55233
Antibody Type
Primary antibody
Isotype
IgG

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