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BMPR-II Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP00833-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP00833-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs| which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors| but they require their respective type I receptors for signaling| whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension| both familial and fenfluramine-associated| and with pulmonary venoocclusive disea
CAS Number
9007-83-4
Synonyms
BMPR-II; Bone morphogenetic protein receptor type-2; BMP type-2 receptor; BMPR-2; EC 2.7.11.30; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Synthesized peptide derived from human BMPR-II
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
114180
Antibody Type
Primary antibody
Isotype
IgG

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