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Vav Polyclonal Antibody

CAT: 0965-JOT-AP09486-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP09486-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
VAV1 (vav guanine nucleotide exchange factor 1) is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for VAV1.
CAS Number
9007-83-4
Synonyms
VAV1; VAV; Proto-oncogene vav
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
Synthesized peptide derived from Vav . at AA range: 110-190
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
98314
Antibody Type
Primary antibody
Isotype
IgG

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