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TRAP230 Polyclonal Antibody

CAT: 0965-JOT-AP09181-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP09181-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1. MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by the gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.
CAS Number
9007-83-4
Synonyms
MED12; ARC240; CAGH45; HOPA; KIAA0192; TNRC11; TRAP230; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human MED12. AA range:611-660
Clonality
Polyclonal
Applications
IHC-p, WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
247334
Antibody Type
Primary antibody
Isotype
IgG

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