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PLB Polyclonal Antibody

CAT: 0965-JOT-AP07256-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP07256-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by PLN (phospholamban)is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in PLN are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
CAS Number
9007-83-4
Synonyms
PLN; PLB; Cardiac phospholamban; PLB
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PLB. AA range:1-50
Clonality
Polyclonal
Applications
IF, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
6109
Antibody Type
Primary antibody
Isotype
IgG

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