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PHKA1/2 Polyclonal Antibody

CAT: 0965-JOT-AP07121-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP07121-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by PHKA1 (phosphorylase kinase regulatory subunit alpha 1). The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in PHKA1 cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.
CAS Number
9007-83-4
Synonyms
PHKA1; PHKA; Phosphorylase b kinase regulatory subunit alpha; skeletal muscle isoform; Phosphorylase kinase alpha M subunit; PHKA2; PHKLA; PYK; Phosphorylase b kinase regulatory subunit alpha, liver
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human KPB1/2. AA range:31-80
Clonality
Polyclonal
Applications
WB, IF, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
137312
Antibody Type
Primary antibody
Isotype
IgG

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