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MYLK Polyclonal Antibody

CAT: 0965-JOT-AP05709-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP05709-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MYLK, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. MYLK encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
CAS Number
9007-83-4
Synonyms
MYLK; MLCK; MLCK1; MYLK1; Myosin light chain kinase; smooth muscle; MLCK; smMLCK; Kinase-related protein; KRP; Telokin
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from MYLK . at AA range: 400-480
Clonality
Polyclonal
Applications
IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
210774
Antibody Type
Primary antibody
Isotype
IgG

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