MMP-1 Polyclonal Antibody

CAT: 0965-JOT-AP05471-01Size: 20 µLDry Ice: NoHazardous: No

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CAT#:0965-JOT-AP05471-01Size:20 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

MMP1 encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Interstitial collagenase in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. MMP1 is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

CAS Number

9007-83-4

Synonyms

MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1

Host

Rabbit

Reactivity

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human MMP-1. AA range:411-460

Clonality

Polyclonal

Applications

WB, IHC-p, IF, ELISA

Stability

-20°C for one year

Concentration

1 mg/ml

Molecular Weight

54007

Antibody Type

Primary antibody

Isotype

IgG

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