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MLKL Polyclonal Antibody

CAT: 0965-JOT-AP05460-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP05460-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MLKL belongs to the protein kinase superfamily. Mixed lineage kinase domain-like protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. Mixed lineage kinase domain-like protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
CAS Number
9007-83-4
Synonyms
MLKL; Mixed lineage kinase domain-like protein
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from MLKL . at AA range: 40-120
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
54479
Antibody Type
Primary antibody
Isotype
IgG

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