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LIMK-2 Polyclonal Antibody

CAT: 0965-JOT-AP05021-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP05021-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by LIMK2 is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Synonyms
LIMK2; LIM domain kinase 2; LIMK-2
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
Synthesized peptide derived from LIMK-2 . at AA range: 440-520
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
72232
Antibody Type
Primary antibody
Isotype
IgG

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