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KIR6.2 Polyclonal Antibody

CAT: 0965-JOT-AP04824-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP04824-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. ATP-sensitive inward rectifier potassium channel 11 encoded by KCNJ11 is an integral membrane protein and inward-rectifier type potassium channel. ATP-sensitive inward rectifier potassium channel 11, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
CAS Number
9007-83-4
Synonyms
KCNJ11; ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel; inwardly rectifying subfamily J member 11
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Kir6.2. AA range:190-239
Clonality
Polyclonal
Applications
WB, IHC-p, IF, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
43562
Antibody Type
Primary antibody
Isotype
IgG

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